At the scene, the driver of the car was sadly pronounced dead.
The victim is believed to be a 38-year-old man and his next of kin have been informed, although he has not been formally identified as of yet.
Police Constable Geraint Williams, of Cheshire Constabulary’s Serious and Complex Collision Investigation Unit, said: “Enquiries in relation to this collision are ongoing and we are keen to hear from anyone who witnessed the incident or has any information which may aid our investigation.
“The A55 is a busy road and I believe that at the time of the incident there could have been a number people in the area, both commuting to work and travelling to Wales, who may have seen what happened and I’d urge them to get in touch.
“The same goes for anyone who was driving in the area and believes they have any dashcam footage which may be relevant to the investigation.